We use computational techniques to develop tangible reactivity models for evaluating how Lewis acids and Lewis bases modulate the reactivity of substrates in chemical reactions.
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Lewis Acid Salts For Disrupting Sulfur-Fluorine Bonds
Overview
In the OMO Lab, we are developing reactivity models for using Lewis acidic salts to facilitate sulfur(VI) fluoride exchange (SuFEx) to form nitrogen-rich sulfur(VI) species
Funding
National Institutes of Health
R15 1R15GM134457-01A1
Ball (PI), Role: co-investigator
05/01/2020-04/30/2023
Select Publications
Calcium Bistriflimide-Mediated Sulfur(VI)–Fluoride Exchange (SuFEx): Mechanistic Insights toward Instigating Catalysis. Han, B.; Khasnavis, S. R.; Nwerem, M.; Bertagna, M.; Ball, N. D.; Ogba, O. M. Inorg. Chem. 2022, 61 (25), 9746–9755. Link
Oxidant Sensing at Bacterial Zinc-Sulfur Sites
Overview
In the OMO Lab, we investigate molecular mechanisms for how bacteria pathogens use zinc complexes to detect host oxidants. Our research in this area has uncovered the likely mechanism in which the mono-cysteine zinc-sulfur site in the cytoplasmic chemoreceptor of H. pylori reacts with HOCl - the most prevalent of the potent biological oxidants
Select Publications
A Bacterial Inflammation Sensor Regulates C-Di-GMP Signaling, Adhesion, and Biofilm Formation. Perkins, A.; Tudorica, D. A.; Teixeira, R. D.; Schirmer, T.; Zumwalt, L.; Ogba, O. M.; Cassidy, C. K.; Stansfeld, P. J.; Guillemin, K. Mbio 2021, 12 (3), e00173-21. Link
Mechanism and Chemoselectivity for HOCl‐Mediated Oxidation of Zinc‐Bound Thiolates. Zumwalt, L.; Perkins, A.; Ogba, O. M. ChemPhysChem 2020, 21 (21), 2384–2387. Link
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